Pathology 1991 Jan;23(1):66-8

A case of childhood hepatitis B virus infection related primary hepatocellula
carcinoma with short malignant transformation time.

Cheah PL, Looi LM, Lin HP, Yap SF
Abstract

Department of Pathology, Faculty of Medicine, University of Malaya, Kuala
Lumpur.

A case of primary hepatocellular carcinoma (PHC) developing in a 10 year old boy
who contracted Hepatitis B virus (HBV) infection in the course of maintenance
phase chemotherapy for acute lymphoblastic leukemia was seen at University
Hospital, Kuala Lumpur. This case is of interest in that it (1) supports an
etiological relationship between HBV infection and PHC, (2) manifested a
distinctly short malignant transformation time, and (3) draws attention to the
possible contributory role of chemotherapy in increasing the risk of developing
PHC